^ - equal contribution authors     * - corresponding authors
  1. Pan L, Zhao W, Lai J, Ding D, Zhang Q, Yang X, Huang M, Jin S, Xu Y, Zeng S, Chou JJ, Chen S: Sortase A-Generated Highly Potent Anti-CD20-MMAE Conjugates for Efficient Elimination of B-Lineage Lymphomas. Small , in press (2016).

  2. Chen B, Chou JJ: Structure of the transmembrane domain of HIV-1 envelope glycoprotein. FEBS J , in press (2016).

  3. Piai A^, Fu Q^, Dev J, Chou JJ: Optimal Bicelle q for Solution NMR Studies of Protein Transmembrane Partition. Chemistry , in press (2016).

  4. Zhao L^, Wang S^, Run C, Ouyang B*, Chou JJ*: Specific Lipid Binding of Membrane Proteins in Detergent Micelles Characterized by NMR and Molecular Dynamics. Biochemistry, 55(38):5317-20 (2016).

  5. Dev J^, Park D^, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B*, Chou JJ: Structural Basis for Membrane Anchoring of HIV-1 Envelope Spike. Science, 353(6295):172-5 (2016).

  6. Oxenoid K^, Dong Y^, Cao C^, Cui T^, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ: Architecture of the mitochondrial calcium uniporter. Nature, 533(7602):269-73 (2016).

  7. Zhao L, Wang S, Du L, Dev J, Zhou L, Liu Z, Chou JJ*, OuYang B*: Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein Cell, 7(4):300-4 (2016). PDF SI

  8. Oxenoid K, Chou JJ: A Functional NMR for Membrane Proteins: Dynamics, Ligand Binding, and Allosteric Modulation. Protein Science, 25(5):959-73 (2016). PDF

  9. Fu Q^, Fu T^, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H*, Chou JJ*: Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Molecular Cell, 61(4):602-13 (2016). PDF SI

  10. Williamson JA^, Cho SH^, Ye J, Collet JF, Beckwith JR, Chou JJ: Structure and Multi-State Function of the Transmembrane Electron Transporter CcdA. Nature Struct Mol Biol, 22(10):809-14 (2015). PDF SI

  11. Andreas LB, Reese M, Eddy MT, Gelev V, Ni QZ, Miller EA, Emsley L, Pintacuda G, Chou JJ, Griffin RG: Structure and Mechanism of the Influenza-A M218-60 Dimer of Dimers. J Am Chem Soc, 137(47):14877-86 (2015). PDF

  12. Chou JJ, Wang J: Transmembrane signaling: A multiplex problem with converging solutions. Progress in Biophysics and Molecular Biology, 118(3):87-8 (2015). PDF

  13. Run C, Yang Q, Liu Z, Ouyang B*, Chou JJ*: Molecular Basis of MgATP Selectivity of the Mitochondrial SCaMC Carrier. Structure, 23(8):1394-403 (2015). PDF SI

  14. Bruschweiler S^, Yang Q^, Run C, Chou JJ: Substrate Modulated Dynamics of the ADP/ATP Transporter Revealed by NMR Relaxation Dispersion. Nature Struct Mol Biol, 22(8):636-41 (2015). PDF SI

  15. Dev J, Bruschweiler S, Ouyang B, Chou JJ: Transverse relaxation dispersion of the p7 membrane channel from Hepatitis C virus reveals conformational breathing. J Biomol NMR, 61(3-4):369-78 (2015). PDF

  16. Sounier R, Bellot G, Chou JJ: Mapping Conformational Heterogeneity of Mitochondrial Nucleotide Transporter in Uninhibited States. Angewandte Chemie, 54(8):2436-41 (2015). PDF SI

  17. Colvin MT, Andreas LB, Chou JJ, Griffin RG: Proton association constants of His 37 in the Influenza-A M218-60 dimer-of-dimers. Biochemistry, 53(38):5987-94 (2014).

  18. Berardi MJ, Chou JJ: Fatty Acid Flippase Activity Of UCP2 Is Essential For Its Proton Transport In Mitochondria. Cell Metabolism, 20(3):541-52 (2014). PDF SI

  19. Barbet-Massin E, Pell AJ, Retel JS, Andreas LB, Jaudzems K, Franks WT, Nieuwkoop AJ, Hiller M, Higman V, Guerry P, Bertarello A, Knight MJ, Felletti M, Le Marchand T, Kotelovica S, Akopjana I, Tars K, Stoppini M, Bellotti V, Bolognesi M, Ricagno S, Chou JJ, Griffin RG, Oschkinat H, Lesage A, Emsley L, Herrmann T, Pintacuda G: Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning. J. Am. Chem. Soc., 136(35):12489-97 (2014).

  20. Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou JJ, Rowlands DJ, Stonehouse NJ, Hogle JM, Tuthill TJ: Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore. PLoS Pathog, 10(8):e1004294 (2014).

  21. Yang Q, Bruschweiler S, Chou JJ: Purification, crystallization and preliminary X-ray diffraction of the N-terminal calmodulin-like domain of the human mitochondrial ATP-Mg/Pi carrier SCaMC1. Acta Crystallogr Sect F Struct Biol Commun, Jan;70(Pt 1):68-71 (2014). PDF

  22. Yang Q, Bruschweiler S, Chou JJ: A self-sequestered calmodulin-like Ca2+ sensor of mitochondrial SCaMC carrier and its implication to Ca2+-dependent ATP-Mg/P(i) transport. Structure, Feb 4;22(2):209-17 (2013). PDF SI

  23. Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A: Coordinating the impact of structural genomics on the human alpha-helical transmembrane proteome. Nature Struct Mol Biol, Feb 4; 20(2):135-8 (2013). PDF

  24. Ouyang B, Chou JJ: The minimalist architectures of viroporins and their therapeutic implications. Biochim Biophys Acta, 1838(4):1058-67 (2013). PDF

  25. Ouyang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B*, Chou JJ*: Unusual architecture of the p7 channel from hepatitis C virus. Nature, Jun 5; 498(7455):521-5 (2013). PDF SI

  26. Oxenoid K, Chou JJ: The present and future of solution NMR in investigating the structure and dynamics of channels and transporters. Curr Opin Struct Biol, Aug; 23(4):547-54 (2013). PDF

  27. Bellot G, McClintock MA, Chou JJ, Shih WM: DNA nanotubes for NMR structure determination of membrane proteins. Nat Protoc, 8(4):755-703 (2013). PDF

  28. Andreas LB, Barnes AB, Corzilius B, Chou JJ, Miller EA, Caporini M, Rosay M, Griffin RG: Dynamic nuclear polarization study of inhibitor binding to the M2(18-60) proton transporter from influenza A. Biochemistry, 52(16):2774-82 (2013). PDF

  29. Sounier R, Chou JJ: Solution nuclear magnetic resonance spectroscopy. Methods Mol Biol, 955:495-517 (2013). PDF

  30. Andreas LB, Eddy MT, Chou JJ, Griffin RG: Magic-angle-spinning NMR of the drug resistant S31N M2 proton transporter from influenza A. J Am Chem Soc, 134(17):7215-8 (2012). PDF

  31. Pielak RM, Oxenoid K, Chou JJ: Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses. Structure, 19(11):1655-63 (2011). PDF

  32. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P: Molecular Basis for Interaction of let-7 MicroRNAs with Lin28. Cell, 147(5):1080-91 (2011). PDF

  33. Berardi MJ, Shih WM, Harrison SC, Chou JJ: Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature, 476(7358):109-13 (2011). PDF

  34. Call ME, Chou JJ: A View into the Blind Spot: Solution NMR Provides New Insights into Signal Transduction Across the Lipid Bilayer. Structure, 18(12):1559-69 (2010). PDF

  35. Pielak RM, Chou JJ: Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus. J. Am. Chem. Soc., 106(18):7379-84 (2010). PDF SI

  36. Call ME, Wucherpfennig KW*, Chou JJ*: The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nature Immunology, 11(11):1023-9 (2010). PDF SI

  37. Pielak RM, Chou JJ: Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem Biophys Res Commun, 401(1):58-63 (2010). PDF

  38. Gagnon E, Xu C, Yang W, Chu HH, Call ME, Chou JJ, Wucherpfennig KW: Response multilayered control of T cell receptor phosphorylation. Cell, 142(5):669-71 (2010).

  39. Andreas LB, Eddy MT, Pielak RM, Chou JJ, Griffin RG: Magic Angle Spinning NMR Investigation of Influenza A M218−60: Support for an Allosteric Mechanism of Inhibition. J. Am. Chem. Soc., 132, 10958-60 (2010). PDF

  40. Pielak RM, Chou JJ: Influenza M2 proton channels. Biochimica et Biophysica Acta, (2010). PDF

  41. Pielak RM, Chou JJ: Flu channel drug resistance: a tale of two sites. Protein & Cell, (2010). PDF

  42. Wang J, Pielak RM, McClintock MA, Chou JJ: Solution structure and functional analysis of the influenza B proton channel. Nature Struct Mol Biol, 16(12):1267-71 (2009). PDF

  43. Chou JJ, Schnell JR: Structure and Mechanism of the M2 Channel In Influenza: Molecular Virology, Q. Wang, and Y.J. Tao, eds. (Norwich, UK, Horizon Scientific Press), chapter 6 (2010).

  44. Pielak RM^, Schnell JR^*, Chou JJ*: Mechanism of drug inhibition and drug resistance of influenza A M2 channel. Proc Natl Acad Sci, 106(18):7379-84 (2009). PDF, Supp Info

  45. Yoon MK^, Venkatachalam V^, Huang A, Choi BS*, Stultz CM*, Chou JJ*: Residual structure within the disordered C-terminal segment of p21Waf1/Cip1/Sdi1 and its implications for molecular recognition. Protein Science, 18(2), 337-347 (2009). PDF

  46. Xu C^, Gagnon E^, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ*, Wucherpfennig KW*: Regulation of T Cell Receptor Activation by Dynamic Membrane Binidng of the CD3e Cytoplasmic Tyrosine-Based Motif. Cell, 135(4), 702-713 (2008). PDF

  47. Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC: Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J Biol Chem, 283(47):32860-9 (2008).

  48. Shen H, Chou JJ: MemBrain: Improving the Accuracy of Predicting Transmembrane Helices. PLoS ONE, 3(6), e2399 (2008). PDF

  49. Schnell JR, Chou JJ: Structure and mechanism of the M2 proton channel of influenza A virus. Nature, 451(7178), 591-5 (2008). PDF

  50. Oxenoid K, Rice AJ, Chou JJ: Comparing the structure and dynamics of phospholamban pentamer in its unphosphorylated and pseudo-phosphorylated states. Protein Science, 16(9), 1977-83 (2007). PDF

  51. Douglas SM, Chou JJ*, Shih WM*: DNA-nanotube-induced alignment of membrane proteins for NMR structure determination. Proc. Natl. Acad. Sci, 104(16), 6644-6648 (2007). PDF

  52. Mansy SS, Zhang J, Kummerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC: Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol, 371, 501-13 (2007). PDF

  53. Kubat JA, Chou JJ, Rovnyak D: Nonuniform sampling and maximum entropy reconstruction applied to the accurate measurement of residual dipolar couplings. J Magn Reson, 186, 201-11, (2007). PDF

  54. Call ME^, Schnell JR^, Xu C, Lutz RA, Chou JJ*, Wucherpfennig KW*: The Structure of the ζζ Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor. Cell, 127(2), 355-368 (2006). PDF

  55. Potluri S, Yan AK, Chou JJ, Donald BR, Bailey-Kellogg C: Structure Determination of Symmetric Homo-Oligomers by a Complete Search of Symmetry Configuration Space, Using NMR Restraints and van der Waals Packing. PROTEINS: Structure, Function, and Bioinformatics, 65, 203-219 (2006). PDF

  56. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC: Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure, 14(6), 1003-9 (2006). PDF

  57. Carothers JM, Davis JH, Chou JJ, Szostak JW: Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA, 12, 567-79 (2006). PDF

  58. Zweckstetter M, Schnell JR, Chou JJ: Determination of the Packing Mode of the Coiled-coil Domain of cGMP-dependent Protein Kinase Ia in Solution Using Charge-Predicted Dipolar Couplings. J. Am. Chem. Soc., 127, 11918-9 (2005). PDF

  59. Schnell, J. R., Zhou, G., Zweckstetter, M., Rigby, A. C., Chou, J. J.: Rapid and Accurate Structure Determination of Coiled-coil Domains Using NMR Dipolar Couplings: Application to cGMP-dependent Protein Kinase Ia. Protein Science, 14(9), 2421-8 (2005). PDF

  60. Oxenoid K, Chou JJ: The structure of phospholamban pentamer reveals a channel-like architecture in membranes. Proc. Natl. Acad. Sci., 102, 10870-10875 (2005). PDF

  61. Zhou X, Chou JJ*, Wong ST*: Protein Structure Similarity Analysis by Using Interaction Matrix Based Principle Component Correlation. BMC Bioinformatics., 7:40 (2006). PDF

  62. Wang JF, Schnell JR, Chou JJ: Amantadine partition and localization in phospholipids membrane: a solution NMR study. Biochem. Biophys. Research Comm., 324, 212-217 (2004). PDF

  63. Chou JJ, Baber JL, Bax A: Characterization of phospholipids mixed micelles by translational diffusion. J. Biol. NMR, 29, 299-308 (2004). PDF

  64. Chou JJ, Case D, Bax A: Insights in mobility of methyl-bearing sidechains in proteins from Jcc and Jcn couplings. J. Am. Chem. Soc., 125, 8959-8966 (2003). PDF

  65. Chou JJ, Kaufman JD, Stahl SJ, Wingfield PT, Bax A: Micelle-Induced Curvature in a Water-Insoluble HIV-1 Env Peptide Revealed by NMR Dipolar Coupling Measurement in Stretched Polyacrylamide Gel. J. Am. Chem. Soc., 124, 2450-2451 (2002). PDF

  66. Chou JJ, Li S, Klee CB, Bax A: Solution structure of Ca2+–calmodulin reveals flexible hand-like properties of its domains.  Nature Structural Biology, 8, 990-997 (2001). PDF

  67. Chou JJ, Bax A: Protein Side-Chain Rotamers from Dipolar Couplings in a Liquid Crystalline Phase. J. Am. Chem. Soc., 123, 3844-3845 (2001).

  68. Bax A, Chou JJ, Ramirez B: Invited Review:  Liquid Crystalline Samples: Application to Macromolecular Structure Determination. Methods in Enzymology (2001).

  69. Chou JJ^, Gaemers S^, Howder B, Louis JM, Bax A: A simple apparatus for generating stretched polyacrylamide gels, yielding uniform alignment of proteins and detergent micelles. J. Biol. NMR, 21, 377-382 (2001).

  70. Chou JJ, Li S, Bax A: Study of Conformational Rearrangement and Refinement of Structural Homology Models by the Use of Heteronuclear Dipolar Couplings. J. Biol. NMR, 18, 217-227 (2000).

  71. Chou JJ, Delaglio F, Bax A: Measurement of One-Bond 15N-13C’ Dipolar Couplings in Medium Sized Proteins. J. Biol. NMR, 18, 101-105 (2000).

  72. Chou JJ, Li H, Salvessen GS, Yuan J, Wagner G: Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling. Cell, 96, 615-624 (1999).

  73. Zhou P, Chou JJ, Olea RS, Yuan J, Wagner G: Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction, Proc. Natl. Acad. Sci., 96, 11265-11270 (1999)

  74. Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G: Solution Structure of the CIDE-N Domain of CIDE-B and a Model for CIDE-N/CIDE-N Interactions in the DNA Fragmentation Pathway of Apoptosis. Cell, 99, 747–755 (1999).

  75. Chou JJ, Matsuo H, Duan H, Wagner G: Solution Structure of the RAIDD CARD Domain and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment. Cell, 94, 171-180 (1998).

  76. Chou JJ, Shakhnovich EI: A Study on Local-Global Cooperativity in Protein Collapse. J. Phys. Chem. B, 103, 2535-2542 (1999).

  77. Chou JJ: A Formulation for Correlating Properties of Peptides and Its Application to Predicting Human Immunodeficiency Virus Protease-Cleavable Sites in Proteins. Biopolymers, 33, 1405-1414 (1993).

  78. Chou JJ: Predicting Cleavability of Peptide Sequences by HIV Protease via Correlation-Angle Approach. J. Protein Chem., 12, 291-302 (1993).

  79. Chou JJ, Zhang CT: A Joint Prediction of the Folding Types of 1490 Human Proteins from their Genetic Codons. J. Theor. Biol., 161, 251-262 (1993).

  80. Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Aristoff PA, Tarpley WG, Reusser F: Steady-state Kinetic Studies with the Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor U-87201E. J Biol Chem., 268, 6119-6124 (1993).

  81. Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Palmer JR, Thomas RC, Aristoff PA, Tarpley WG, Reusser F: Kinetic Studies with the Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor U-88204E. Biochemistry, 32, 6548-6554 (1993).

  82. Althaus IW, Gonzales AJ, Chou JJ, Romero DL, Deibel MR, Chou KC, Kezdy FJ, Rensnick L, Busso ME, So AG, Downey KM, Thomas RC, Aristoff PA, Tarpley WG, Reusser F: The Quinoline U-78036 is a Potent Inhibitor of HIV-1 Reverse Transcriptase. J. Biol. Chem., 268, 14875-14880 (1993).

©2005 Chou Research Group