^ - equal contribution authors     * - corresponding authors
  1. Chen W, Dev J, Mezhyrova J, Pan L, Piai A, Chou JJ: The Unusual Transmembrane Partition of the Hexameric Channel of the Hepatitis C Virus. Structure, in press (2018).

  2. Yang J, Piai A, Shen HB, Chou JJ: An Exhaustive Search Algorithm to Aid NMR-Based Structure Determination of Rotationally Symmetric Transmembrane Oligomers. Sci Rep, 7(1):17373 (2017).

  3. Piai A, Dev J, Fu Q, Chou JJ: Stability and Water Accessibility of the Trimeric Membrane Anchors of the HIV-1 Envelope Spikes. J Am Chem Soc, 139(51):18432-18435 (2017). PDF SI

  4. Zhao L, Wang S, Zhu Q, Wu B, Liu Z, OuYang B, Chou JJ: Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid. Structure, 25(9):1371-1379 (2017). PDF

  5. Cao C, Wang S, Cui T, Su XC, Chou JJ: Ion and inhibitor binding of the double-ring ion selectivity filter of the Mitochondrial Calcium Uniporter. PNAS, 114(14):E2846-E2851 (2017). PDF

  6. Pan L, Zhao W, Lai J, Ding D, Zhang Q, Yang X, Huang M, Jin S, Xu Y, Zeng S, Chou JJ, Chen S: Sortase A-Generated Highly Potent Anti-CD20-MMAE Conjugates for Efficient Elimination of B-Lineage Lymphomas. Small , 13(6) (2017). PDF

  7. Piai A^, Fu Q^, Dev J, Chou JJ: Optimal Bicelle q for Solution NMR Studies of Protein Transmembrane Partition. Chemistry, 23(6):1361-1367 (2017). PDF SI

  8. Chen B, Chou JJ: Structure of the transmembrane domain of HIV-1 envelope glycoprotein. FEBS J , 284(8):1171-1177 (2016). PDF

  9. Zhao L^, Wang S^, Run C, Ouyang B*, Chou JJ*: Specific Lipid Binding of Membrane Proteins in Detergent Micelles Characterized by NMR and Molecular Dynamics. Biochemistry, 55(38):5317-20 (2016). PDF SI

  10. Dev J^, Park D^, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B*, Chou JJ: Structural Basis for Membrane Anchoring of HIV-1 Envelope Spike. Science, 353(6295):172-5 (2016). PDF SI

  11. Oxenoid K^, Dong Y^, Cao C^, Cui T^, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ: Architecture of the mitochondrial calcium uniporter. Nature, 533(7602):269-73 (2016). PDF

  12. Zhao L, Wang S, Du L, Dev J, Zhou L, Liu Z, Chou JJ*, OuYang B*: Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein Cell, 7(4):300-4 (2016). PDF SI

  13. Oxenoid K, Chou JJ: A Functional NMR for Membrane Proteins: Dynamics, Ligand Binding, and Allosteric Modulation. Protein Science, 25(5):959-73 (2016). PDF

  14. Fu Q^, Fu T^, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H*, Chou JJ*: Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Molecular Cell, 61(4):602-13 (2016). PDF SI

  15. Williamson JA^, Cho SH^, Ye J, Collet JF, Beckwith JR, Chou JJ: Structure and Multi-State Function of the Transmembrane Electron Transporter CcdA. Nature Struct Mol Biol, 22(10):809-14 (2015). PDF SI

  16. Andreas LB, Reese M, Eddy MT, Gelev V, Ni QZ, Miller EA, Emsley L, Pintacuda G, Chou JJ, Griffin RG: Structure and Mechanism of the Influenza-A M218-60 Dimer of Dimers. J Am Chem Soc, 137(47):14877-86 (2015). PDF

  17. Chou JJ, Wang J: Transmembrane signaling: A multiplex problem with converging solutions. Progress in Biophysics and Molecular Biology, 118(3):87-8 (2015). PDF

  18. Run C, Yang Q, Liu Z, Ouyang B*, Chou JJ*: Molecular Basis of MgATP Selectivity of the Mitochondrial SCaMC Carrier. Structure, 23(8):1394-403 (2015). PDF SI

  19. Bruschweiler S^, Yang Q^, Run C, Chou JJ: Substrate Modulated Dynamics of the ADP/ATP Transporter Revealed by NMR Relaxation Dispersion. Nature Struct Mol Biol, 22(8):636-41 (2015). PDF SI

  20. Dev J, Bruschweiler S, Ouyang B, Chou JJ: Transverse relaxation dispersion of the p7 membrane channel from Hepatitis C virus reveals conformational breathing. J Biomol NMR, 61(3-4):369-78 (2015). PDF

  21. Sounier R, Bellot G, Chou JJ: Mapping Conformational Heterogeneity of Mitochondrial Nucleotide Transporter in Uninhibited States. Angewandte Chemie, 54(8):2436-41 (2015). PDF SI

  22. Colvin MT, Andreas LB, Chou JJ, Griffin RG: Proton association constants of His 37 in the Influenza-A M218-60 dimer-of-dimers. Biochemistry, 53(38):5987-94 (2014).

  23. Berardi MJ, Chou JJ: Fatty Acid Flippase Activity Of UCP2 Is Essential For Its Proton Transport In Mitochondria. Cell Metabolism, 20(3):541-52 (2014). PDF SI

  24. Barbet-Massin E, Pell AJ, Retel JS, Andreas LB, Jaudzems K, Franks WT, Nieuwkoop AJ, Hiller M, Higman V, Guerry P, Bertarello A, Knight MJ, Felletti M, Le Marchand T, Kotelovica S, Akopjana I, Tars K, Stoppini M, Bellotti V, Bolognesi M, Ricagno S, Chou JJ, Griffin RG, Oschkinat H, Lesage A, Emsley L, Herrmann T, Pintacuda G: Rapid Proton-Detected NMR Assignment for Proteins with Fast Magic Angle Spinning. J. Am. Chem. Soc., 136(35):12489-97 (2014). PDF

  25. Panjwani A, Strauss M, Gold S, Wenham H, Jackson T, Chou JJ, Rowlands DJ, Stonehouse NJ, Hogle JM, Tuthill TJ: Capsid Protein VP4 of Human Rhinovirus Induces Membrane Permeability by the Formation of a Size-Selective Multimeric Pore. PLoS Pathog, 10(8):e1004294 (2014).

  26. Yang Q, Bruschweiler S, Chou JJ: Purification, crystallization and preliminary X-ray diffraction of the N-terminal calmodulin-like domain of the human mitochondrial ATP-Mg/Pi carrier SCaMC1. Acta Crystallogr Sect F Struct Biol Commun, Jan;70(Pt 1):68-71 (2014). PDF

  27. Yang Q, Bruschweiler S, Chou JJ: A self-sequestered calmodulin-like Ca2+ sensor of mitochondrial SCaMC carrier and its implication to Ca2+-dependent ATP-Mg/P(i) transport. Structure, Feb 4;22(2):209-17 (2013). PDF SI

  28. Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, Stroud RM, Stevens RC, Sali A: Coordinating the impact of structural genomics on the human alpha-helical transmembrane proteome. Nature Struct Mol Biol, Feb 4; 20(2):135-8 (2013). PDF

  29. Ouyang B, Chou JJ: The minimalist architectures of viroporins and their therapeutic implications. Biochim Biophys Acta, 1838(4):1058-67 (2013). PDF

  30. Ouyang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B*, Chou JJ*: Unusual architecture of the p7 channel from hepatitis C virus. Nature, Jun 5; 498(7455):521-5 (2013). PDF SI

  31. Oxenoid K, Chou JJ: The present and future of solution NMR in investigating the structure and dynamics of channels and transporters. Curr Opin Struct Biol, Aug; 23(4):547-54 (2013). PDF

  32. Bellot G, McClintock MA, Chou JJ, Shih WM: DNA nanotubes for NMR structure determination of membrane proteins. Nat Protoc, 8(4):755-703 (2013). PDF

  33. Andreas LB, Barnes AB, Corzilius B, Chou JJ, Miller EA, Caporini M, Rosay M, Griffin RG: Dynamic nuclear polarization study of inhibitor binding to the M2(18-60) proton transporter from influenza A. Biochemistry, 52(16):2774-82 (2013). PDF

  34. Sounier R, Chou JJ: Solution nuclear magnetic resonance spectroscopy. Methods Mol Biol, 955:495-517 (2013). PDF

  35. Andreas LB, Eddy MT, Chou JJ, Griffin RG: Magic-angle-spinning NMR of the drug resistant S31N M2 proton transporter from influenza A. J Am Chem Soc, 134(17):7215-8 (2012). PDF

  36. Pielak RM, Oxenoid K, Chou JJ: Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses. Structure, 19(11):1655-63 (2011). PDF

  37. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P: Molecular Basis for Interaction of let-7 MicroRNAs with Lin28. Cell, 147(5):1080-91 (2011). PDF

  38. Berardi MJ, Shih WM, Harrison SC, Chou JJ: Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature, 476(7358):109-13 (2011). PDF

  39. Call ME, Chou JJ: A View into the Blind Spot: Solution NMR Provides New Insights into Signal Transduction Across the Lipid Bilayer. Structure, 18(12):1559-69 (2010). PDF

  40. Pielak RM, Chou JJ: Kinetic Analysis of the M2 Proton Conduction of the Influenza Virus. J. Am. Chem. Soc., 106(18):7379-84 (2010). PDF SI

  41. Call ME, Wucherpfennig KW*, Chou JJ*: The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nature Immunology, 11(11):1023-9 (2010). PDF SI

  42. Pielak RM, Chou JJ: Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel. Biochem Biophys Res Commun, 401(1):58-63 (2010). PDF

  43. Gagnon E, Xu C, Yang W, Chu HH, Call ME, Chou JJ, Wucherpfennig KW: Response multilayered control of T cell receptor phosphorylation. Cell, 142(5):669-71 (2010).

  44. Andreas LB, Eddy MT, Pielak RM, Chou JJ, Griffin RG: Magic Angle Spinning NMR Investigation of Influenza A M218−60: Support for an Allosteric Mechanism of Inhibition. J. Am. Chem. Soc., 132, 10958-60 (2010). PDF

  45. Pielak RM, Chou JJ: Influenza M2 proton channels. Biochimica et Biophysica Acta, (2010). PDF

  46. Pielak RM, Chou JJ: Flu channel drug resistance: a tale of two sites. Protein & Cell, (2010). PDF

  47. Wang J, Pielak RM, McClintock MA, Chou JJ: Solution structure and functional analysis of the influenza B proton channel. Nature Struct Mol Biol, 16(12):1267-71 (2009). PDF

  48. Chou JJ, Schnell JR: Structure and Mechanism of the M2 Channel In Influenza: Molecular Virology, Q. Wang, and Y.J. Tao, eds. (Norwich, UK, Horizon Scientific Press), chapter 6 (2010).

  49. Pielak RM^, Schnell JR^*, Chou JJ*: Mechanism of drug inhibition and drug resistance of influenza A M2 channel. PNAS, 106(18):7379-84 (2009). PDF, Supp Info

  50. Yoon MK^, Venkatachalam V^, Huang A, Choi BS*, Stultz CM*, Chou JJ*: Residual structure within the disordered C-terminal segment of p21Waf1/Cip1/Sdi1 and its implications for molecular recognition. Protein Science, 18(2), 337-347 (2009). PDF

  51. Xu C^, Gagnon E^, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ*, Wucherpfennig KW*: Regulation of T Cell Receptor Activation by Dynamic Membrane Binidng of the CD3e Cytoplasmic Tyrosine-Based Motif. Cell, 135(4), 702-713 (2008). PDF

  52. Sharma AK, Zhou GP, Kupferman J, Surks HK, Christensen EN, Chou JJ, Mendelsohn ME, Rigby AC: Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase. J Biol Chem, 283(47):32860-9 (2008).

  53. Shen H, Chou JJ: MemBrain: Improving the Accuracy of Predicting Transmembrane Helices. PLoS ONE, 3(6), e2399 (2008). PDF

  54. Schnell JR, Chou JJ: Structure and mechanism of the M2 proton channel of influenza A virus. Nature, 451(7178), 591-5 (2008). PDF

  55. Oxenoid K, Rice AJ, Chou JJ: Comparing the structure and dynamics of phospholamban pentamer in its unphosphorylated and pseudo-phosphorylated states. Protein Science, 16(9), 1977-83 (2007). PDF

  56. Douglas SM, Chou JJ*, Shih WM*: DNA-nanotube-induced alignment of membrane proteins for NMR structure determination. PNAS, 104(16), 6644-6648 (2007). PDF

  57. Mansy SS, Zhang J, Kummerle R, Nilsson M, Chou JJ, Szostak JW, Chaput JC: Structure and evolutionary analysis of a non-biological ATP-binding protein. J Mol Biol, 371, 501-13 (2007). PDF

  58. Kubat JA, Chou JJ, Rovnyak D: Nonuniform sampling and maximum entropy reconstruction applied to the accurate measurement of residual dipolar couplings. J Magn Reson, 186, 201-11, (2007). PDF

  59. Call ME^, Schnell JR^, Xu C, Lutz RA, Chou JJ*, Wucherpfennig KW*: The Structure of the ζζ Transmembrane Dimer Reveals Features Essential for Its Assembly with the T Cell Receptor. Cell, 127(2), 355-368 (2006). PDF

  60. Potluri S, Yan AK, Chou JJ, Donald BR, Bailey-Kellogg C: Structure Determination of Symmetric Homo-Oligomers by a Complete Search of Symmetry Configuration Space, Using NMR Restraints and van der Waals Packing. PROTEINS: Structure, Function, and Bioinformatics, 65, 203-219 (2006). PDF

  61. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC: Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure, 14(6), 1003-9 (2006). PDF

  62. Carothers JM, Davis JH, Chou JJ, Szostak JW: Solution structure of an informationally complex high-affinity RNA aptamer to GTP. RNA, 12, 567-79 (2006). PDF

  63. Zweckstetter M, Schnell JR, Chou JJ: Determination of the Packing Mode of the Coiled-coil Domain of cGMP-dependent Protein Kinase Ia in Solution Using Charge-Predicted Dipolar Couplings. J. Am. Chem. Soc., 127, 11918-9 (2005). PDF

  64. Schnell, J. R., Zhou, G., Zweckstetter, M., Rigby, A. C., Chou, J. J.: Rapid and Accurate Structure Determination of Coiled-coil Domains Using NMR Dipolar Couplings: Application to cGMP-dependent Protein Kinase Ia. Protein Science, 14(9), 2421-8 (2005). PDF

  65. Oxenoid K, Chou JJ: The structure of phospholamban pentamer reveals a channel-like architecture in membranes. PNAS., 102, 10870-10875 (2005). PDF

  66. Zhou X, Chou JJ*, Wong ST*: Protein Structure Similarity Analysis by Using Interaction Matrix Based Principle Component Correlation. BMC Bioinformatics., 7:40 (2006). PDF

  67. Wang JF, Schnell JR, Chou JJ: Amantadine partition and localization in phospholipids membrane: a solution NMR study. Biochem. Biophys. Research Comm., 324, 212-217 (2004). PDF

  68. Chou JJ, Baber JL, Bax A: Characterization of phospholipids mixed micelles by translational diffusion. J. Biol. NMR, 29, 299-308 (2004). PDF

  69. Chou JJ, Case D, Bax A: Insights in mobility of methyl-bearing sidechains in proteins from Jcc and Jcn couplings. J. Am. Chem. Soc., 125, 8959-8966 (2003). PDF

  70. Chou JJ, Kaufman JD, Stahl SJ, Wingfield PT, Bax A: Micelle-Induced Curvature in a Water-Insoluble HIV-1 Env Peptide Revealed by NMR Dipolar Coupling Measurement in Stretched Polyacrylamide Gel. J. Am. Chem. Soc., 124, 2450-2451 (2002). PDF

  71. Chou JJ, Li S, Klee CB, Bax A: Solution structure of Ca2+–calmodulin reveals flexible hand-like properties of its domains.  Nature Structural Biology, 8, 990-997 (2001). PDF

  72. Chou JJ, Bax A: Protein Side-Chain Rotamers from Dipolar Couplings in a Liquid Crystalline Phase. J. Am. Chem. Soc., 123, 3844-3845 (2001).

  73. Bax A, Chou JJ, Ramirez B: Invited Review:  Liquid Crystalline Samples: Application to Macromolecular Structure Determination. Methods in Enzymology (2001).

  74. Chou JJ^, Gaemers S^, Howder B, Louis JM, Bax A: A simple apparatus for generating stretched polyacrylamide gels, yielding uniform alignment of proteins and detergent micelles. J. Biol. NMR, 21, 377-382 (2001).

  75. Chou JJ, Li S, Bax A: Study of Conformational Rearrangement and Refinement of Structural Homology Models by the Use of Heteronuclear Dipolar Couplings. J. Biol. NMR, 18, 217-227 (2000).

  76. Chou JJ, Delaglio F, Bax A: Measurement of One-Bond 15N-13C’ Dipolar Couplings in Medium Sized Proteins. J. Biol. NMR, 18, 101-105 (2000).

  77. Chou JJ, Li H, Salvessen GS, Yuan J, Wagner G: Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling. Cell, 96, 615-624 (1999).

  78. Zhou P, Chou JJ, Olea RS, Yuan J, Wagner G: Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction, Proc. Natl. Acad. Sci., 96, 11265-11270 (1999)

  79. Lugovskoy AA, Zhou P, Chou JJ, McCarty JS, Li P, Wagner G: Solution Structure of the CIDE-N Domain of CIDE-B and a Model for CIDE-N/CIDE-N Interactions in the DNA Fragmentation Pathway of Apoptosis. Cell, 99, 747–755 (1999).

  80. Chou JJ, Matsuo H, Duan H, Wagner G: Solution Structure of the RAIDD CARD Domain and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment. Cell, 94, 171-180 (1998).

  81. Chou JJ, Shakhnovich EI: A Study on Local-Global Cooperativity in Protein Collapse. J. Phys. Chem. B, 103, 2535-2542 (1999).

  82. Chou JJ: A Formulation for Correlating Properties of Peptides and Its Application to Predicting Human Immunodeficiency Virus Protease-Cleavable Sites in Proteins. Biopolymers, 33, 1405-1414 (1993).

  83. Chou JJ: Predicting Cleavability of Peptide Sequences by HIV Protease via Correlation-Angle Approach. J. Protein Chem., 12, 291-302 (1993).

  84. Chou JJ, Zhang CT: A Joint Prediction of the Folding Types of 1490 Human Proteins from their Genetic Codons. J. Theor. Biol., 161, 251-262 (1993).

  85. Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Aristoff PA, Tarpley WG, Reusser F: Steady-state Kinetic Studies with the Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor U-87201E. J Biol Chem., 268, 6119-6124 (1993).

  86. Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Palmer JR, Thomas RC, Aristoff PA, Tarpley WG, Reusser F: Kinetic Studies with the Non-nucleoside HIV-1 Reverse Transcriptase Inhibitor U-88204E. Biochemistry, 32, 6548-6554 (1993).

  87. Althaus IW, Gonzales AJ, Chou JJ, Romero DL, Deibel MR, Chou KC, Kezdy FJ, Rensnick L, Busso ME, So AG, Downey KM, Thomas RC, Aristoff PA, Tarpley WG, Reusser F: The Quinoline U-78036 is a Potent Inhibitor of HIV-1 Reverse Transcriptase. J. Biol. Chem., 268, 14875-14880 (1993).

©2005 Chou Research Group